Marjolin's ulcers commonly arise on chronic wounds, irritated skin areas and have a potential to transform into squamous cell skin cancer (SCC). These lesions have a poor prognosis and differentiation when transformed into squamous cell cancer. When transformed to squamous cell cancer this malignant skin tumor can cause recurrent metastasis and death. This condition had shows a variety of curative treatment modality. Amputation can be a surgical treatment in cases that have positive lymph node and bone invasion. Herein, we present two cases with skin squamous cell cancer involving the left cubital area and posterior thigh arising from the burn scar leading to extremity amputation.